Anthony J. Veloso, Hiroyuki Yoshikawa, Xin R.
Cheng, Eiichi Tamiya, and Kagan Kerman
Alzheimer's disease (AD) is marked by the accumulation of
neuronal plaques from insoluble amyloid-beta (Aβ) peptides. Growing evidence
for the role of Aβ oligomers in neuronal cell cytotoxicity and pathogenesis has
prompted the development of novel techniques to better understand the early
stages of aggregation. Near infrared (NIR) optical trapping was applied to
characterize the early stages of Aβ aggregation in the presence of a β-sheet
intercalating dye, Congo Red (CR), as the fluorescent marker. The integration
of fluorescence analysis with NIR optical trapping has provided a new outlook
into the first two hours of Aβ aggregation.
Journal: Analyst
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