Alice Pyne, Ruth Thompson, Carl Leung, Debdulal Roy and Bart W. Hoogenboom
Based on soft-touch atomic force microscopy, a method is described to reconstruct the secondary structure of single extended biomolecules, without the need for crystallization. The method is tested by accurately reproducing the dimensions of the B-DNA crystal structure. Importantly, intramolecular variations in groove depth of the DNA double helix are resolved, which would be inaccessible for methods that rely on ensemble-averaging.
DOI
Journal: Small
Simon Kheifets, Akarsh Simha, Kevin Melin, Tongcang Li, Mark G. Raizen
Measurement of the instantaneous velocity of Brownian motion of suspended particles in liquid probes the microscopic foundations of statistical mechanics in soft condensed matter. However, instantaneous velocity has eluded experimental observation for more than a century since Einstein’s prediction of the small length and time scales involved. We report shot-noise–limited, high-bandwidth measurements of Brownian motion of micrometer-sized beads suspended in water and acetone by an optical tweezer. We observe the hydrodynamic instantaneous velocity of Brownian motion in a liquid, which follows a modified energy equipartition theorem that accounts for the kinetic energy of the fluid displaced by the moving bead. We also observe an anticorrelated thermal force, which is conventionally assumed to be uncorrelated.
DOI
Journal: Science
Stefan Müllegger, Mohammad Rashidi, Karlheinz Mayr, Michael Fattinger, Andreas Ney, and Reinhold Koch
We report a new type of nanomechanical resonator system based on one-dimensional chains of only 4 to 7 weakly coupled small molecules. Experimental characterization of the truly nanoscopic resonators is achieved by means of a novel radio-frequency scanning tunneling microscopy detection technique at cryogenic temperatures. Above 20 K we observe concerted oscillations of the individual molecules in chains, reminiscent of the first and second eigenmodes of a one-dimensional harmonic resonator. Radio-frequency scanning tunneling microscopy based frequency measurement reveals a characteristic length dependence of the oscillation frequency (between 51 and 127 MHz) in reasonable agreement with one-dimensional oscillator models. Our study demonstrates a new strategy for investigating and controlling the resonance properties of nanomechanical oscillators.
DOI
Journal:Physical Review Letters
