Random-Coil:α-Helix Equilibria as a Reporter for the LewisX–LewisX Interaction

1. Timothy M. Altamore, 
2. Christian Fernández-García, 
3. Andrew H. Gordon, 
4. Tina Hübscher, 
5. Dr. Netnapa Promsawan, 
6. Maxim G. Ryadnov, 
7.  Andrew J. Doig, 
8. Derek N. Woolfson, 
9. Timothy Gallagher

1. Probing weak interactions: A peptide random-coil:α-helix equilibrium has been used to identify a weak carbohydrate–carbohydrate interaction (CCI). Glucose and lactose destabilized the helical conformer while Lewis^X trisaccharide led to increased helicity. Though small, the trend observed indicates that this peptide reporter can detect a single CCI in isolation.

1. DOI

1. Journal: Angewandte Chemie